Around 75 medication competitors dependent on synlet quality sets are being assessed for the therapy of different sorts

Advances in screening technologies have enabled the identification of interactive gene combinations

Advances in screening technologies have enabled the identification of interactive gene combinations, enabling the development of lead candidates that leverage the principle of synthetic lethality for cancer treatment


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The USD 8 billion (by 2030) financial opportunity within the synthetic lethality-based drugs and targets market has been analyzed across the following segments:

  • Type of molecule
  • Small Molecule
  • Biologic


  • Target disease indication
  • Breast Cancer
  • Colorectal Cancer
  • Fallopian Tube Cancer
  • Gastric Cancer
  • Head and Neck Cancer
  • Lung Cancer
  • Ovarian Cancer
  • Peritoneal Cancer
  • Others


  • Type of synlet target
  • APE1 / Ref-1
  • Chk1
  • GLS1
  • PARP
  • Pol θ
  • PP2A
  • Wee1


  • Route of administration
  • Oral
  • Intravenous


  • Key geographical regions
  • North America
  • Europe
  • Asia Pacific
  • Rest of the World


The, report features the following companies, which we identified to be key players in this domain:

  • AbbVie
  • AstraZeneca
  • AtlasMedx
  • BeiGene
  • Chordia Therapeutics
  • Clovis Oncology
  • GlaxoSmithKline
  • IDEAYA Biosciences
  • Mission Therapeutics
  • Pfizer
  • Repare Therapeutics
  • Sierra Oncology
  • SyntheX Labs


Table of Contents


  1. Preface

    2. Executive Summary

  2. Introduction to DNA Damage and Repair Systems

  3. Introduction to Synthetic Lethality

  4. Market Overview

  5. Company Profiles

  6. Emerging Trends on Social Media

  7. Publication Analysis

  8. Abstract Analysis

  9. Academic Grants Analysis

  10. Funding and Investment Analysis

  11. Target Benchmark Analysis


  1. Role of Companion Diagnostics in Synthetic Lethality


  1. Market Forecast

  2. Concluding Remarks

  3. Executive Insights


  1. Appendix 1: Tabulated Data


  1. Appendix 2: List of Companies and Organizations



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